Claudia M. Witt, MD, MBA

portrait of claudia witt

Home Institution: University of Zurich

Field: Integrative and Digital Health Interventions

Current Positions: 

My Driving Question

How can clinical research generate better evidence to help people make more informed choices?

Scholar Project

Dr. Witt believes that Comparative Effectiveness Research (CER) and participatory research have the potential to unlock much of the evidence that can increase choices available to patients, especially those suffering from chronic disease. As a Nova Institute Scholar, Dr. Witt has been engaged in the development of Effectiveness Guidance Documents for CER, teaching clinical research methods and CER to international audiences, and generating papers in subjects ranging from acupuncture research guidance to the impact of corporate culture on mergers involving integrative medicine services and digital health approaches.


Comparative Effectiveness Research (CER): CER provides better evidence for better decisions, and Dr. Witt is focused on advancing the field of CER for complementary and integrative medicine. With the development of recommendations and Effectiveness Guidance Documents, she has made a landmark contribution for future research.

Corporate culture principles from mergers in Integrative Medicine: The integration of conventional and complementary medicines in a hospital or clinic requires the “marriage” of two distinct cultures in an effort to provide integrative health care services. By exploring the principles of corporate culture as used for mergers in the business world, Dr. Witt has been at work to develop a set of recommendations that facilitate smooth transitions for health care entities interested in the implementation of integrative medicine services.

International Research Training: Dr. Witt provides hand-on research methodology trainings. Her instruction focuses on two key areas:  basic study design and basic statistics and the design of pragmatic trials for CER.


Claudia Witt is a full professor at the Medical Faculty of the UZH and director of the Institute for Complementary and Integrative Medicine of the University Hospital Zurich. She is a physician and epidemiologist and holds a Master of Business Administration (MBA) in Health Care Management.

From 2017-2021, she was Vice Dean for Interprofessionalism and Internationality of the Medical Faculty of the UZH. She heads the doctoral program for Care and Rehabilitation Science and is co-director of the Digital Society Initiative at the UZH. She is also part-time Professor for Primary Care at the University of Maryland School of Medicine in Baltimore. Before her appointment to Zurich, she worked at the Charité – Universitätsmedizin Berlin at the Institute for Social Medicine, Epidemiology and Health Economics, which she last headed provisionally and held a Professorship for Complementary Medicine.

Claudia Witt’s research focuses on the evaluation of non-pharmacological interventions in integrative medicine, as well as non-specific factors such as therapy outcomes. To answer her research questions, she engages stakeholders and applies methods of clinical research, health economics, implementation science and neuroimaging. In her current research, participatory and digital health aspects play an important role; she has been conducting clinical studies on mobile health interventions since 2011. She advocates a reflective approach to digitalization in medicine. 

Her publications could be accessed here.

Curriculum Vitae

See Dr. Witt’s CV

Selected Publications

Comparative Effectiveness Research


Research Training

Healing is facilitated through safety, persistence, and trust.

  • Persistence: “People did not simply progress through this sequence and experience healing. The healing journey was a recursive, back and forth process. They found helpers, used the skills/resources that those helpers provided, found other helpers that provided more resources and used those skills and resources. As this process continued, people experienced a gradual amelioration of their suffering. Although many despaired at times, all demonstrated the quality of persistence—they refused to give up.”
  • Safety & Trust: “To connect to helpers, it was essential for people to feel safe in those relationships and able to trust that the person would be a helper and not a barrier to healing. Persons whose wounds included a violation of trust were especially careful about testing the safety of new relationships.”

Resources support us as we heal. They include reframing, responsibility, and positivity. “Making connections enabled participants to acquire and refine resources and skills that were essential in their healing journey. People also brought their own personal strengths to the journey.”

  • Reframing: “A particularly important skill was the ability to reframe—that is to look at suffering through a different lens.” This does NOT mean minimizing trauma or pain, but rather it often means the opposite: understanding what happened was wrong, unfair, or uncontrollable and that we are not to blame for it.
  • Responsibility: While we don’t have control over what happened to us, we are the only ones who can help ourselves heal. “A third essential resource that people acquired or refined was the ability to take an appropriate amount of responsibility for their healing journeys. They participated actively in the process of healing. Once again, some participants already had developed this skill, and some acquired or refined it from their helpers.”
  • Positivity: “Another resource that people acquired or refined during their healing journey was choose to be positive—that is to have some optimism about their situation.” People have varying predispositions to positivity. In the study, positivity was important in helping people heal. This doesn’t mean a toxic positivity, but rather simply finding some good in life and feeling hopeful about our situations.

“Connection to others was an essential part of all the healing journeys.” Humans are social creatures, and even the most introverted of us need close relationships. Friends and family add meaning and value to life and help support us, in good times and bad. 

When we experience relational trauma, relationships can feel scary, but reestablishing safety and trust in relationships is where the healing happens. (To be clear, we do not mean reestablishing safety and trust with abusers, but rather finding other healing relationships.) 

“When safety and trust had been established, people were able to connect with helpers. The nature of the behaviours of helpers that fostered healing ranged from small acts of kindness to unconditional love.”

  • “Moving from being wounded, through suffering to healing, is possible. It is facilitated by developing safe, trusting relationships and by positive reframing that moves through the weight of responsibility to the ability to respond.”
  • “Relationships with health professionals were among these but were not necessarily any more important to the healing journey than other kinds of helpers, which included family members, friends, spirituality and their God, pets, support groups, administrators, case workers and supervisors.”

Healing probably means different things to different people, but one definition that emerged from the study is: “The re-establishment of a sense of integrity and wholeness.” 

Healing was an emergent property that resulted from each individuals’ complex healing journey, a result of bridged connections between resources and relationships. “…they gradually found relief from suffering and began to exhibit emergent characteristics: a sense of hope, self-acceptance, and a desire to help others—the immediate precursors to healing.”

 In varying degrees, “they were able to transcend their suffering and in some sense to flourish.” 

  • Helping Others: We find meaning in helping others. “Understanding that suffering gives the strength and experience to help others in similar situations.”
  • Hope: We begin to have hope that we will not always feel this bad. A Crohn’s patient said, “I think gradually I realized that I was going to feel better. I did have days when I actually didn’t vomit, when I did feel better. And I think gradually I came to believe that maybe I could have a normal life again.”
  • Self-Acceptance: We see our inherent value and understand that we are not to blame for our suffering. A participant living with HIV said, “I’m really proud of myself. I think that now I still want to live. I don’t want to die, and I really love myself a lot. I have a lot of comfort in myself.”

Suffering is the ongoing pain from wounding. 

There is debate about whether or not one actually needs to experience suffering on the path to healing.

Wounding happens when we experience physical or emotional harm. It can stem from chronic illness or by physical or psychological trauma for which we do not have the tools to cope, or a combination of those factors. 

“The degree and quality of suffering experienced by each individual is framed by contextual factors that include personal characteristics, timing of their initial or ongoing wounding in the developmental life cycle and prior and current relationships.”

Characteristics: How predisposed someone may be to wounding/how many tools and resources someone may have to deal with trauma/illness.

Lifestages: Developmental timing plays an important role in the impact of trauma — young children often do not have the same resources as older adults.

Relationships: Relationships can provide solace and support for those suffering, while lack of healthy relationships can prolong suffering.